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    • 专利摘要:
    We propose a method and apparatus to estimate the time of transit of the aortic pulse (ptt) from only temporal intervals measured between fiducial points of the longitudinal balistocardiogram (bcg) without the need to apply any sensor in the area where it is desired to detect the arrival of the arterial pulse wave. From the longitudinal bcg of a subject, which can be obtained by sensors integrated in a single element with which the body of the subject comes into contact, two fiducial points of the bcg waveform are detected in which one of the points it is associated with the arrival of the arterial pulse wave to a zone proximal to the heart and the other is associated with the arrival of said arterial pulse wave to a distal zone, respectively. From the time interval between the two points, an estimation of the aortic ptt (carotid-femoral) is provided directly or through a previous calibration process. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2607721A1
    申请号:ES201531414
    申请日:2015-10-02
    公开日:2017-04-03
    发明作者:Ramón Pallàs Areny；Ramón CASANELLA ALONSO；Joan GÓMEZ CLAPERS
    申请人:Universitat Politecnica de Catalunya UPC；
    IPC主号:
    专利说明:

    SECTOR OF THE TECHNIQUE
    The present invention relates in general to physiological parameter measurement systems by physical methods and, in particular, to a method and apparatus for estimating the transit time of the aortic pulse from temporal intervals measured exclusively between fiducial points of the balistocardiogram ( BCG).
    15 STATE OF THE TECHNIQUE
    The pulse transit time (Pulse Transit Time or PTT) generated by the ejection of blood from the heart to the arterial system is a very important parameter to diagnose the state of the cardiovascular system. It is defined as the time interval 20 between the arrival of the pulse wave at a point proximal to the heart and the arrival at another distal point, and from it you can evaluate, for example, arterial elasticity, which is an indicator every increasingly accepted to predict the risk of cardiovascular disease. Arterial elasticity has been associated with the presence of cardiovascular risk factors and arteriosclerotic diseases, and 25 its ability to predict the risk of future cardiovascular events such as myocardial infarction, stroke, revascularization or aortic syndromes, among others, has been widely corroborated, as described in the document by C. Vlachopoulos, K. Aznaouridis, and C. Stefanadis, "Prediction of Cardiovascular Events and AII-cause Mortality With Arterial Stiffness: a Systematic Review and Meta
    30 analysis, ~ Journal American College Cardiology, vol. 55, no. 13, pp. 1318-27, Mar. 2010.
    The degree of elasticity of an artery is normally evaluated from the pulse wave velocity (Pulse Wave Velocityo PWV), according to the formula described by Moens-Korteweg,
    pwv = JEh,
    2Tp
    where E is the modulus of elasticity of the artery, h is the thickness of the arterial wall, r is the radius of the artery and p is the density of the blood.
    The measurement of PWV in the aorta is the one of greatest clinical relevance because the aorta and its
    5 main ramifications are responsible for most of the pathophysiological effects derived from arterial stiffness, so that aortic PWV is a good indicator of the state of stiffness of the subject's arteries. The high predictivity of aortic PWV with respect to cardiovascular events has been demonstrated in different epidemiological studies, as described in the document of L. M. Van 80rtel,
    10 S. Laurent, P. Boutouyrie, P. Chowienczyk, J. K. Cruickshank, et aL, "Expert Consensus Document on the Measurement of Aortic Stiffness in Daily Practice Using Carotid-Femoral Pulse Wave Velocity,"; Journal Hypertension, vol. 30, no. 3, pp. 445448, Mar. 2012.
    15 The measurement of PWV in an artery is generally performed non-invasively from PTT in that artery, according to
    D
    PWV = PTT '
    where D is the distance between the proximal point and the distal point considered. In the case of aortic PWV, the measurement is usually performed between the carotid point, located in the medial area of the anterior border of the sternocieidomastoid muscle, and
    20 the femoral point located in the medial area of the inguinal fold. The arteries at these points are superior, so they are easily accessible for a sensor that establishes good contact with the skin, and the transit time of the pulse wave between them adequately reflects the aortic PTT since it includes much of the aortic and aortic-iliac propagation.
    25 Another parameter that can be measured from the elasticity of an artery is blood pressure, since the modulus of elasticity is related to changes in mean arterial pressure P according to
    Eoe kP
    E = where Eo is the modulus of elasticity of the artery at an average blood pressure of 30 reference and k is a constant dependent on the artery and whose value is between
    0.016 mmHg-1 and 0.018 mmHg-1. Changes in PTT induced by changes in the modulus of elasticity of the aorta, and in other arteries, can be used to estimate changes in blood pressure, and also absolute pressure values by different calibration methods, as described by example in the document of
    5 D. Buxi, J. M. Redouté, and M. R. Yuce, "A Survey on Signals and Systems in Ambulatory Blood Pressure Monitoring Using Pulse Transit Time,"; Physiological Measurements, DDI10.1088 / 0967-3334 / 36/3 / R1.
    The usual procedure to measure aortic PTT non-invasively involves
    10 preparation (exposure, cleaning, placement of the sensor and cable connection) of the carotid and femoral points to detect in each of them the arrival of the pulse wave, for example by means of a photoplethysmograph (PPG) or an impedance plethysmograph ( IPG) that detect the change in local volume due to the arrival of the arterial pulse, or by means of an arterial tonometer that measures the pressure exerted by a
    15 superficial artery on a force sensor in close contact with it. These and other sensors capable of detecting the arrival of the arterial pulse wave require expertise in their placement, lead to slow measurement and are uncomfortable for the subject. In addition, prolonged application of the sensor may cause discomfort in the subject, which makes it advisable to perform the measurement for periods of time.
    20 long due to the possible physiological repercussions of the measurement action.
    An alternative way of obtaining information on the mechanical activity derived from cardiac ejection in the aorta, which causes the pulse wave, and which requires less preparation of the subject, is to determine the temporary position of fiducial points 25 of the balistocardiogram (BCG), It reflects the variations experienced by the center of gravity of the human body, either in the form of displacement, velocity or acceleration, as a result of the ejection of blood in each beat and the subsequent spread of the pressure pulse through the arterial network. The BCG can be obtained in multiple ways, some of which can be implemented with sensors 30 incorporated in everyday objects, for example bathroom scales, chairs or beds, as detailed in the document of OT Inan, PF Migeotte, K .-S. Park,
    M. Etemadi, K. Tavakolian, et al., "Ballistocardiography and Seismocardiography: a Review of Recent Advances,"; IEEE Journal of Biomedical Health and Informatics, DOI
    10.11 09 / JBHI.2014.2361732, or incorporated in clothing, such as footwear 35 or socks. These solutions allow to obtain the BCG quickly and comfortably, and in some cases for long periods of time, because sensors are not placed on the points of the body where it is desired to detect the arrival of the arterial pulse wave but rather is the body the one that comes into contact naturally with an element (platform, scale, chair, bed, clothing) where the elements are incorporated
    5 BCG sensors.
    Until now, BCG fiducial points have been used as proximal time references in time interval measurements due to the relationship between that signal and the moment of blood ejection in each beat. That is
    10 the case of US 20130310700 A1, in which it is proposed to use BCG fiducial points obtained from a system integrated in a domestic scale as a proximal temporal reference for measuring aortic PTT. The method described in said patent has the disadvantage that it needs an additional sensor to detect the arrival of the arterial pulse wave at the distal point considered.
    15 Obtaining proximal and distal temporal information in the same BCG signal would allow aortic PTT to be measured more quickly and comfortably even for long periods of time, which would be very useful for evaluating arterial elasticity and its derived parameters. It would also serve to calculate other indicators
    20 where the aortic PTT intervenes along with other cardiovascular parameters, for example in the determination of myocardial contractility from the pre-ejection period (PEP), obtained by calculating the difference between the time of arrival of the Pulse wave (Press Arrival Time or PAT) and the PTT.
    25 BRIEF DESCRIPTION OF THE INVENTION
    The invention consists of a method and apparatus for estimating the transit time of the aortic pulse (PTT) as defined in the independent claims. The dependent claims define preferred embodiments of the
    30 invention. In the present description and claims it has been considered that the aortic PTT is the PTT between the carotid point, located in the medial area of the anterior border of the sternocleidomastoid muscle, and the femoral point located in the medial area of the inguinal fold.
    The innovative solution proposed by the present invention is the estimation of aortic PTT from time intervals measured exclusively between BCG fiducial points. Since this signal is usually obtained by sensors integrated in a single element with which the subject's body comes into contact, the use of the BCG avoids the need for additional pulse wave sensors and the
    The inconvenience of having to place these sensors in the specific areas where it is desired to detect the arrival of the arterial pulse wave.
    This innovative solution is based on the fact that BCG waves reflect changes in the center of gravity of the human body derived from the superposition of the 10 effects of cardiac ejection and the propagation of the arterial pulse wave. Therefore, it is expected that the most initial points of the BCG regarding cardiac systole are mostly related to events related to cardiac ejection, while it is expected that the fiducial points farther from the start of the signal with respect to cardiac systole are most influenced by events related to
    15 the arrival of the pulse wave to distal areas. Since the aorta is comparatively the artery with the highest blood volume and its orientation is longitudinal (parallel to the head-to-foot axis), it is expected that the longitudinal BCG waves are especially influenced by the mechanical activity derived from the propagation of the wave of pulse that occurs in that main artery.
    20 Consequently, a method is proposed to estimate aortic PTT consisting, first, of detecting two fiducial points of a BCG: a first point plausibly related to the arrival of the pulse wave to more proximal areas with respect to the heart and a second point later in time
    25 plausibly related to the arrival of the pulse wave to more distal areas. Next, the time interval between these two fiducial points is measured. This interval corresponds, in a first way to obtain it, directly with the aortic PTT. A second alternative way of obtaining said transit time from the time interval measured between the two points
    30 fiducial is to calibrate the interval obtained from the BCG using as reference the aortic PTT obtained simultaneously with one of the known methods belonging to the state of the art. Using the ratio obtained in the calibration, in subsequent measurements the aortic PTT can be calculated from the interval obtained exclusively from the BCG, thus achieving greater accuracy than in the
    35 first proposed way, although with a slower and more complex initial procedure.
    Applying the proposed method, the inventors have found that, specifically, waves I and J of the BCG are systematically coincident with the arrival of the pulse wave at the carotid and femoral points, respectively, so the IJ interval
    5 is especially suitable for obtaining aortic PTT directly from it, in accordance with the first proposed method of obtaining it. The use of the second method, based on the calibration of the IJ interval, is also suitable if a more accurate measurement of aortic PTT is desired.
    10 On the other hand, it is expected that the intervals measured between other arbitrarily chosen fiducial points of the longitudinal BCG are equally sensitive to changes in the PTT in the aorta, such as the interval between waves I and K, or the interval between waves J and K, although the different duration of these intervals with respect to the aortic PTT will entail the use of the second method of obtaining aortic PTT
    15, based on the previous calibration of the relationship between the interval considered and the aortic PTT measured with any of the conventional methods.
    Although the proposed method could be implemented by an expert who knew the temporal relationships between the BCG waves and the arrival of the pulse wave at 20 different points of the arterial network described in this invention patent, and that visually identified the fiducial points , within the same beat, in a BCG register and manually measure the time interval between them, an optimal implementation is by means of an apparatus containing the signal processing systems necessary to automatically detect the two first and 25 second fiducial points. in a BGC signal, the calculation systems necessary to calculate the time interval between said fiducial points and to obtain the aortic PTT from said interval, and which finally contained a obtained PTT communication system that is responsible for its representation in a display element or of the communication of the value to another device. An algorithm capable of detecting and measuring the time interval between waves I and J from only the BCG signal may be, for example, the one proposed in the document of A. Akhbardeh, B. Kaminska and K. Tavakolian, quot ; 88eg ++: A modified Blind Segmentation Method for Ballistocardiogram Cycle Extraction, quot; Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2007, pp. 1896-1899. Other algorithms belonging to the state of the art use an additional cardiovascular signal such as
    temporal origin to detect waves I and J instead of using only BCG itself. For example, in the document of Inan et al. cited above (DOI 10.1109 / JBHI.2014.2361732) it is proposed to detect the J wave from the measurement of the local maximum at a BCG interval after the R peak of the
    5 electrocardiogram (ECG). This method is easily replicable from other cardiovascular signals such as, for example, PPG, locally measured IPG, or IPG measured between extremities, signals that can be obtained in distal areas of the body for comfort.
    The invention described herein has the main advantage that it allows obtaining aortic PTT using only fiducial points of the balistocardiogram, which facilitates the measurement of aortic PTT more easily, quickly and comfortably even for long periods of time with respect to those systems that require signals other than BCG to obtain at least one of the two fiducial points between which
    15 a time interval related to aortic PTT is measured, or that detects the arrival of the arterial pulse wave by placing one or more sensors in the areas between which the PTT is to be measured.
    DESCRIPTION OF THE DRAWINGS
    In order to complement the description that is being made and in order to help a better understanding of the characteristics of the invention, a set of drawings is attached as an integral part of this description, where with an illustrative and non-limiting nature, the next:
    Figure 1 - Shows a diagram of a bathroom scale capable of obtaining the BCG and constituting the element with which the subject comes into contact in one of the embodiments of the present invention.
    30 Figure 2 - Shows the typical BCG waveform, measured in a standing subject and where the main waves 1, J, K, L, M and N that make up the BCG in each beat and the IJ interval are detailed . The origin of the abscissa axis coincides with the R peak of the electrocardiogram (ECG), although this signal is not essential to measure the IJ interval.
    Figure 3 - It shows, from top to bottom, a record of the ECG (represented to facilitate the understanding of the invention but that is not essential to measure intervals between BCG points), the BCG obtained with a scale, the photoplethysmogram (PPG) in the carotid point and the PPG at the femoral point, all measured simultaneously in a
    5 same subject.
    Figure 4 - Shows a trace of the IJ interval of the BCG and the carotid-femoral PTT
    obtained simultaneously in the same subject during a rhythmic breathing maneuver to induce changes in arterial elasticity due to variations in blood pressure associated with breathing.
    Figure 5 - Shows the linear regression analysis and the Bland-Altman analysis of 407 pairs of simultaneous measurements of the IJ interval and the carotid-femoral PTT.
    15 Figure 6 - Shows a trace of the IK interval of the BCG and the carotid-femoral PTT obtained simultaneously in the same subject during a rhythmic breathing maneuver to induce changes in arterial elasticity due to variations in blood pressure associated with respiration
    EMBODIMENTS OF THE INVENTION
    In a preferred embodiment of the invention, a system integrated in a bathroom scale (1) obtains a longitudinal BCG indicative of the mechanical activity derived from
    25 cardiac ejection in the aorta, from a sensor (2) formed by the strain gauges themselves used by the scale to measure body weight and an analog signal processing circuit (3), as shown in Figure 1 .
    From the BCG obtained at the exit of the described system, the method to estimate the
    The transit time of the aortic pulse consists, first, in detecting two fiducial points in said BCG by digital signal processing: a first point related to the arrival of the arterial pulse wave to more proximal areas, which in this embodiment would correspond to the minimum of wave 1, and a second point, related to the arrival of the arterial pulse wave to more distal areas, than in this
    The embodiment would correspond to the maximum of the J wave. Next, the digital signal processing system (4) that is being used in this preferred embodiment to detect said fiducial points measures the time interval between them, which in this preferred embodiment is the time interval between the minimum of the I wave and the maximum of the J wave, called the IJ interval, in each beat. Said interval IJ is
    5 would correspond, in a first way to obtain it, with the aortic PTT. Finally, the communication module (5) is responsible for communicating the estimated value of the aortic PTT of the subject through an lCD monitor.
    An example of the BCG of one of these beats is shown in Figure 2, where
    10 indicate waves I and J And the measured IJ interval is this case. Figure 3 shows simultaneously in the same subject the ECG, the BCG, and the carotid and femoral PPG that allow obtaining the aortic PPT by the traditional method that implies the need to place the pulse sensors (PPG) in the respective areas of the body where it is desired to detect the arrival of the arterial pulse wave. This figure illustrates the
    15 correspondence between the minimum of the I wave and the foot of the arterial pulse wave at the carotid point (6), and between the maximum of the J wave and the foot of the arterial pulse wave at the femoral point (7) , and how, consequently, it is possible to obtain the aortic PTT from only two fiducial points of the BCG if the method proposed in this preferred embodiment of the invention is followed.
    To illustrate the correspondence between the IJ interval and the aortic PTT in this embodiment, the carotid-femoral PTT (obtained from the carotid and femoral PPG) and the IJ interval in the same subject during a rhythmic breathing maneuver, which induces Changes in arterial elasticity due to variations in blood pressure, as shown in Figure 4. Figure 5 shows the linear regression analysis and the Bland-Altman analysis of 407 pairs of simultaneous measurements of the IJ interval and the PTT carotid-femoral, obtained in various subjects under rhythmic respiration, which illustrate the good agreement between both parameters. Since the duration of the IJ interval is similar to the duration of the aortic PTT and the
    30 variations in both parameters introduced by rhythmic respiration have an equivalent magnitude, in this preferred embodiment the IJ interval is directly used as a substitute for aortic PTT and the difference between intervals (mean -5.2 ms and standard deviation 13.2 ms in the group analyzed in figure 5) is considered part of the intrinsic uncertainty of the measure.
    To improve the accuracy in obtaining the aortic PTT, a second way of determining it is proposed in which the relationship between the IJ interval and the aortic PTT is obtained by prior calibration. In this preferred embodiment, a linear regression is calculated between the IJ interval and the aortic PTT, obtained from the measurement
    5 simultaneous of both intervals in a group of interest or a representative part of it, which allows aortic PTT to be estimated more accurately in subsequent measurements from only the IJ interval through the equation of the straight line obtained.
    Figure 6 shows the data obtained in another preferred embodiment, in which the
    PTT is estimated from the interval between the minimum of the I wave and the minimum of the K wave, which is the so-called IK interval. The result is shown together with the carotid-femoral PTT measured simultaneously in the same subject during a rhythmic breathing maneuver. As with the IJ interval in Figure 4, the IK interval reflects the changes in the carotid-femoral PTT induced by the maneuver but now
    15 are increased because their duration is greater than that of the IJ interval, so, in this embodiment, the carotid-femoral PTT is necessarily obtained from the calibration of the IK interval with respect to the carotid-femoral PTT measured with other means
    Once the invention has been sufficiently described, as well as three preferred embodiments, it should only be added that it is possible to make modifications in its constitution, materials used, and in the choice of the sensors used to obtain the BCG and the methods for identifying fiducial points. of this BCG, without departing from the scope of the invention, defined in the following claims.
    权利要求:
    Claims (1)
    [1]
    1 -A method to estimate the transit time of the aortic pulse (PTT) from the interval between fiducial points of the balistocardiogram (BCG) characterized in that
    a) a first fiducial point is detected in the BCG;b) a second fiducial point is detected in the BCG subsequent in time tofirst but within the same beat;c) the time interval between the first point and the second point is measured
    10 fiducial; d) the aortic PTT is obtained from the time interval measured between the two chosen fiducial points.
    2 - The method according to claim 1, characterized in that the first and second fiducial points of the BCG are detected using exclusively the BCG signal.
    3. The method according to claim 1, characterized in that the two fiducial points of the BCG are identified from an auxiliary cardiovascular signal.
    The method according to claim 3, characterized in that a beat is detected at
    from the R peak of the electrocardiogram and the two fiducial points of the BCG are detected at defined intervals with respect to the R peak of the electrocardiogram, corresponding to the same beat.
    25 5 -The method according to claim 3, characterized in that a beat is detected from the foot of the pulse wave of a photoplethysmogram or an impedance plethysmogram and the two fiducial points of the BCG are detected at defined intervals with respect to the foot of said pulse wave corresponding to the same beat.
    The method according to one of claims 4 or 5 characterized in that the two fiducial points of the BGC detected are points I and J.
    7 - The method according to one of claims 4 or 5 characterized in that the two
    BCG fiducial points detected are points I and K.
    8 -The method according to one of claims 4 or 5, characterized in that the two
    BCG fiducial points detected are points J and K.
    9. The method according to any of claims 1 to 6, characterized in that the5 interval between BCG fiducial points is measured between waves I and J.
    10 - The method according to any of claims 1 to 5 or 7, characterized
    because the interval between BCG fiducial points is measured between waves I and K.
    The method according to any of claims 1 to 5 or 8, characterized in that the interval between fiducial points of the BCG is measured between the J and K waves.
    12 - The method according to any of claims 1 to 6 or 9, characterized in that the aortic PTT estimated from the interval between fiducial points of the BCG 15 corresponds directly to the interval obtained between the BCG points detected.
    13 - The method according to any of claims 1 to 12, characterized in that the estimated aortic PTI is obtained by means of the relationship between said PTI and the time interval between fiducial points of the BCG, said relationship being obtained from the calibration of said interval with respect to another method of obtaining aortic PTT.
    The method according to claim 13, characterized in that said calibration comprises performing a linear regression between the time interval between 25 fiducial points of the BCG and the aortic PTI obtained by another method, preferably obtained from a photoplethysmogram or a impedance plethysmogram.
    The method according to claim 14, characterized in that the fiducial points of the BCG are points I and J. 30
    16 - The method according to claim 14, characterized in that the fiducial points of the BCG are points I and K.
    17 -A device to automatically estimate the pulse transit time
    35 (PTI) aortic from the interval between fiducial points of the balistocardiogram (BCG), comprising:
    a) a digital signal processing system capable of automatically detecting two fiducial points in a BGC signal, within the same beat,
    5 separated in time; b) a calculation system capable of obtaining the time interval between the two fiducial points; c) a communication system capable of communicating the obtained aortic PTI to a user or to another device.
    The apparatus according to claim 17, characterized in that it additionally comprises a second calculation system capable of obtaining the aortic PTI from said time interval.
    The apparatus according to one of claims 17 or 18, characterized in that it comprises means for input of an auxiliary signal and means for determining an extreme value in the BGC signal after a reference point in said auxiliary signal
    The apparatus according to claim 19, characterized in that said auxiliary signal is an impedance plethysmogram, a photoplethysmogram or an electrocardiogram.
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